What meds have taken that gave you the worst side effects?

For me, Topomax was the worst. I had no appetite and no taste for food. I lost so much weight that my co-workers made regular comments to me, such as "Kerri, you have to tell me what diet you are on". It annoyed me a lot, but it wasn't their fault. I told them, "It's a simple diet. Just become epileptic, take four different meds and you won't have an appetite either. " Not many people asked about my weight loss after I said that.